🔬 Science Backed Formula

What are the science-backed benefits of each ingredient in GLP+ CraveCut™❓

Each ingredient in GLP+ CraveCut™ was selected based on strong scientific evidence supporting its metabolic, glycemic, or appetite-regulating effects. Here's a breakdown with clinical references:

🔬 Berberine 

Berberine has been clinically shown to activate AMPK — a key metabolic regulator — and improve insulin sensitivity. Additionally, experimental studies in cell lines have confirmed that berberine and its metabolites stimulate GLP‑1 secretion and reduce blood glucose levels.

  • AMPK activation: Eg. Efficacy of Berberine in Patients with Type 2 Diabetes shows AMPK activation in humans. 
  • GLP‑1 increase: Modulation of glucagon-like peptide-1 release by berberine demonstrates increased GLP‑1 secretion in rats and cells.
  • Metabolite data: Review shows metabolites of berberine stimulate GLP‑1 release in animal models.

🔬 L-Glutamine 

L‑Glutamine taken before meals has been shown in clinical trials to significantly increase GLP‑1 and insulin responses while reducing post-meal blood sugar levels in individuals with type 2 diabetes. It also supports gut barrier function and satiety signaling, making it effective for curbing sugar cravings.

  • Primary study: Glutamine‑augmented GLP‑1 and insulin response in type 2 diabetes — PMID 25412338

Glutamine increases GLP‑1 and insulin excursions and reduces postprandial glycemia in type 2 diabetes patients.

🔬 Mangiferin 

Potent DPP-4 inhibitor, antioxidant, and antidiabetic compound derived from mango leaves.

Mechanism & Benefits:

  • DPP-4 inhibition: Natural inhibitor shown to block the enzyme responsible for degrading GLP‑1, thereby supporting prolonged appetite regulation and insulin release.
  • Antioxidant & Metabolic Support: Reduces oxidative stress and improves lipid metabolism and insulin sensitivity in diabetic and metabolic syndrome models.

Scientific Evidence:

  • In vitro & in vivo animal studies confirm that mangiferin significantly inhibits DPP‑4 and improves insulin resistance, inflammation, and lipid profile in diabetic models
  • In silico docking data demonstrates strong binding affinity of mangiferin to DPP‑4's active site, comparable to pharmaceutical inhibitors like vildagliptin 

Mangiferin is a proven natural DPP‑4 inhibitor that works synergistically with GLP‑1 pathways — reducing enzyme breakdown, supporting blood sugar balance, and protecting cells with antioxidant benefits.

🔬 Quercetin 

Natural DPP-4 inhibitor, antioxidant, and supporter of β-cell function.

Mechanism & Benefits:

  • Inhibits DPP-4, the enzyme that degrades GLP‑1, thereby helping to maintain higher levels of this appetite-regulating hormone.
  • Antioxidant activity & anti-inflammatory, supports pancreatic β-cell health and improves glucose metabolism.

Scientific Evidence:

  • In vitro and animal studies show Quercetin inhibits DPP-4 activity and improves metabolic markers in diabetic rats 
  • Review in Life (Basel) (2022) confirms Quercetin inhibits DPP-IV and α-glucosidase enzymes, extending the half-life of GLP‑1 and improving insulin function in metabolic studies.

“Quercetin is a natural flavonoid shown to inhibit DPP‑4 — the enzyme that breaks down GLP‑1 — and support insulin secretion and antioxidant defenses. Animal models and review studies confirm its role in prolonging satiety hormone action and improving metabolic health.”

🔬 Apigenin (100 mg)

A stress-relief flavonoid that supports appetite control, sleep quality, and hormonal balance — making it a key ally against emotional eating and metabolic imbalance.

Mechanism & Benefits:

Apigenin is a plant compound that helps reduce emotional eating by lowering cortisol and promoting calm, restful sleep. It also offers antioxidant support for overall metabolic balance, making it a powerful complement to our DPP‑4 inhibitors.

🔬 Green Tea Extract – EGCG 

Supports thermogenesis, fat oxidation, metabolic health, and inhibits DPP-4.

Verified Benefits & Evidence:

  • Enhanced fat oxidation & thermogenesis
    Multiple studies show that daily intake of green tea extract rich in EGCG (~270–366 mg EGCG with ~150 mg caffeine) increases fat oxidation by up to 20%—both at rest and during exercise.
  • Weight management & metabolic benefits
    Animal studies confirm EGCG reduces body weight gain and adipose tissue in high‑fat diet mice through AMPK activation in adipose and muscle tissue.
  • DPP‑4 inhibition & antidiabetic action
    In vitro and animal data confirm EGCG inhibits DPP‑4 enzyme activity (IC₅₀ = ~28 µM), helping to preserve GLP‑1 levels.

Green tea extract (200 mg EGCG) supports metabolic health through multiple validated mechanisms: it boosts thermogenesis and fat oxidation, promotes AMPK activation for energy and weight control, and naturally inhibits the DPP‑4 enzyme—helping maintain GLP‑1 activity for improved appetite regulation.

🔬 Ginger Extract

Supports digestion, improves insulin sensitivity, promotes metabolic health, and offers antioxidant and anti-inflammatory benefits.

Verified Benefits & Evidence:

  • Improves insulin sensitivity & blood sugar control:
    A meta-analysis of 10 randomized controlled trials (490 participants) indicates that ginger supplementation significantly reduces fasting glucose, HbA1c, fasting insulin, and HOMA‑IR — markers of improved insulin sensitivity 
  • Supports metabolic syndrome & lipid profile:
    Systematic reviews and RCTs show ginger reduces blood glucose, insulin resistance, and triglycerides in type 2 diabetics and individuals with metabolic syndrome
  • Antioxidant and anti-inflammatory effects:
    Studies demonstrate ginger’s bioactive compounds (gingerol, shogaol) help reduce oxidative stress and inflammation, supporting cellular and metabolic health.

Ginger extract is supported by clinical evidence for enhancing insulin sensitivity, improving blood glucose control, and supporting digestive health and metabolism. Its antioxidant and anti-inflammatory properties further protect metabolic function and support overall wellness.

🔬 Inulin

A prebiotic fiber that enhances gut health and supports endogenous GLP‑1 production — leading to better satiety, metabolic balance, and digestion.

Verified Benefits & Evidence:

  • Promotes GLP‑1 secretion & satiety:
    Animal studies show that inulin-type fructans increase GLP‑1 levels, PYY, and L‑cell density in the colon, reducing food intake and improving glucose metabolism 
  • Supports appetite regulation & weight management:
    A clinical RCT in prediabetic individuals (30 g/day) reported enhanced weight loss maintenance, lower ectopic fat, and increased GLP‑1 after meals versus placebo 
  • Improves metabolic markers:
    Inulin fermentation produces SCFAs (like propionate and butyrate), which stimulate GLP‑1 secretion through GPR43 receptors and enhance insulin sensitivity, supporting overall glucose homeostasis 

Inulin is a prebiotic fiber that selectively feeds beneficial gut bacteria, increasing production of short-chain fatty acids which stimulate GLP‑1 and PYY hormones. This leads to improved satiety, better appetite control, and healthier glucose metabolism.”

🔬 Multi-Strain Probiotics (4B CFU)

Live beneficial bacteria designed to support gut health and help stimulate endogenous GLP‑1 production, improving satiety and metabolic function.

Verified Benefits & Evidence:

  • Increases GLP‑1 via gut metabolites:
    A mouse study using the VSL#3 probiotic blend showed increased production of short-chain fatty acids (like butyrate), leading to higher GLP‑1 secretion, reduced food intake, and improved glucose tolerance and insulin sensitivity. 
  • Enhances metabolic health:
    Probiotic supplementation in human and animal models has demonstrated improvements in insulin sensitivity, body weight regulation, and decreased inflammation—factors closely linked to GLP‑1 and metabolic control. (Meta-analyses support general benefits of probiotics on metabolic syndrome)

“Our proprietary multi‑strain probiotic blend aids digestion and supports a healthy gut microbiome. It boosts production of short-chain fatty acids like butyrate, which in turn stimulate GLP‑1 secretion—helping to enhance natural satiety, support blood sugar balance, and reduce food cravings.”

🔬 Chromium Picolinate

Supports blood sugar regulation, improves insulin sensitivity, and may help reduce food cravings.

Verified Benefits & Evidence:

“Chromium picolinate (200 µg) is clinically supported for improving insulin sensitivity and helping to regulate blood sugar—including in individuals with insulin resistance. Some users also report reduced carbohydrate cravings and modest weight support.”

🔬 Ashwagandha (KSM-66)

A premium adaptogen that reduces stress, lowers cortisol, improves sleep, and supports emotional well-being.

Verified Benefits & Evidence:

Ashwagandha (KSM‑66, 300 mg) is a clinically proven adaptogen that lowers cortisol and reduces stress after 60 days of use. Users report improved sleep and resilience, supported by antioxidant and hormonal balancing effects—making it ideal for emotional well‑being and appetite control.

🔬 Zinc Bisglycinate (10–15 mg)

Supports insulin function, metabolic balance, and immune health.

Verified Benefits & Evidence:

  • Enhances glucose metabolism & insulin sensitivity
    An umbrella meta-analysis of clinical trials showed that zinc supplementation significantly reduced fasting blood sugar (−13.6 mg/dL), HbA1c (−0.35%), fasting insulin, and HOMA‑IR — demonstrating improved glycemic control in individuals with or at risk for type 2 diabetes
  • Plays a key role in insulin storage and secretion
    Experimental studies indicate that zinc is essential for insulin crystallization in pancreatic β‑cells, influencing insulin synthesis, secretion, and action 
  • Boosts antioxidant defenses and immune function
    Zinc acts as an antioxidant, stabilizes cellular membranes, and supports immune responses — helping protect metabolic tissues from oxidative stress and inflammation 

Zinc bisglycinate (10–15 mg) is included to support healthy insulin production and glucose control—clinical evidence shows it can reduce fasting blood sugar, HbA1c, insulin levels, and insulin resistance. Plus, it acts as an antioxidant and supports immune health.